2011年4月20日星期三

New therapy for enlarged Prostate may circumvent the unpleasant side effects (HealthDay)

By Amanda Gardner
HealthDay Reporter by Amanda Gardner
HealthDay Reporter - Kills the 29 March, 11: 47 pm and

TUESDAY, March 29 (HealthDay News) - a minimally invasive treatment for hypertrophy of the prostate which limits the blood supply to the prostate appears to be just as effective as surgery, but without the risk of debilitating side effects, such as impotence and urinary incontinence.

Treatment - called benign prostate or EAP artery embolization - is ready to be used in some patients, namely those with a prostate plue of 60 cubic centimetres, "with serious lower urinary tract symptoms and a weak urinary stream""," said Mr. Jo?o Martins Pisco, senior author of a study to be presented on March 29 at the annual meeting of the society of Interventional Radiology in Chicago.

But other experts are not so sure.

Drugs are used to treat most of the patients with hypertrophy of the prostate, with only about 10 per cent of qualifying for surgery to remove the gland together, said Dr. Elizabeth Kavaler, a urologist at Lenox Hill Hospital in New York.

"Because the drug is so effective, most of the patients we treat surgically are in very poor condition", she added. And while this study has shown some symptomatic improvement, it was not sufficient objective data to show that the new technique would surgery, she said.

Hyperplasia, benign prostate, also known under the name hypertrophy of the prostate, is a non-cancerous condition familiar to millions of older males. The condition occurs when the prostate enlarges slowly and press on the urethra, constricting the flow of urine.

Enlarged prostate is characterized by a host of unpleasant symptoms, including low urine flow or slow, an urgent need to urinate often, incomplete bladder emptying and having to get up several times during the night to urinate.

Surgery for enlarged prostate - Transurethral resection of the prostate or TURP - is used for men whose prostate is smaller than 60-80 cubic centimeters. The procedure is performed under general anesthesia and requires a hospital stay.

During this time, there is no size limit for PAE, which requires only local anesthesia and also decreases the risk of other side effects, such as the loss of blood and ejaculation retrograde, which occurs when semen leaks in the bladdersaid researchers. EAP can be both an external consultation procedure.

For the procedure, a catheter is inserted into the femoral artery in the groin. The catheter offer "grains" of tiny arteries that lead to the prostate, which block the blood flow and lead to shriveling ' gland.

In this study, EAP has contributed to most of the 67 patients who have undergone a procedure, according to researchers, who had noticed that 66 men who had not responded to the drug have experienced improvements in symptoms and a reduction in prostate volume. After nine months, none had experienced sexual dysfunction and 25 percent still reported improvements.

However, the authors have not seen as large 'urodynamic' results improved, as flow improved urine, which would indicate how the bladder and urethra are one; in this area, patient does not improve as much as those who had undergone surgery TURP, they noted.

Another drawback is that some doctors are trained to the EAP so far, said Pisco, Chairman of Radiology at hospital Pulido Valente and medical professor at the Faculty of science at the new University of Lisbon in the Portugal.

Other minimally invasive treatments for prostate hypertrophy that are currently available are less effective and have a higher risk of a need for reoperation, according to the information documents that accompanied the study.

Dr. Franklin Lowe, Director associate of Urology at the Hospital of St. Luke's - Roosevelt in New York City, said PAE is "probably" not much used to treat enlarged prostate.

Current surgical procedures generally require no more than a night at the hospital and complications such as incontinence and impotence are rare, he said.

"EAP is potentially dangerous complications,"Lowe said, adding that the follow-up to the study of less than one year was short for a disease that lasts decades.""

Given that the study is presented at a medical meeting and has not yet been published in a journal of peer, the conclusions should be considered preliminary.

More information

The National Institutes of Health, the United States has more information on hypertrophy of the prostate.


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